Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme promoter contains composite elements inducible by nuclear receptors pregnane X receptor and constitutive androstane receptor, synergizing effects by HNF4alpha binding at a site near the promoter, overview | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene SULT2A1, expression and regulation analysis, the enzyme promoter contains composite elements inducible by nuclear receptors pregnane X receptor, PXR, and constitutive androstane receptor, CAR, synergizing effects by HNF4alpha binding at a site near the promoter, overview | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | disruption of the DR4-type motif and the IR2-type motif prevents in vitro binding of nuclear receptors pregnane X receptor and constitutive androstane receptor to their specific binding sites, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme promotes phase II metabolism through its sulfonating action on certain endobiotics, including steroids and bile acids, and on diverse xenobiotics, including therapeutics drugs, regulation of enzyme expression involving HNF4alpha, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2 cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme promotes phase II metabolism through its sulfonating action on certain endobiotics, including steroids and bile acids, and on diverse xenobiotics, including therapeutics drugs, regulation of enzyme expression involving HNF4alpha, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
steroid-/bile acid-sulfotransferase | - |
Homo sapiens |
SULT2A1 | - |
Homo sapiens |